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Owing to their decrease in ACE inhibitor-induced side effects, angiotensin II receptor antagonists are often recommended in place of an ACE inhibitor; however, there are rare reports of this agent inducing bronchospasm. Malaria is discussed in more detail in Chapter 115. Skin is an essential part of the body. Acute opioid poisoning can produce life-threatening effects that typically include respiratory depression and coma that may lead to death. For the chapter in the Wells Handbook, please go to Chapter 35. Pain Management. To provide an example of this technique, the problem given previously for conventional dosing will be extended to include steady-state concentrations. The use of traditional healers and CAM is a cross-cultural phenomenon. Centrolobular necrosis, steatohepatitis (steatonecrosis), phospholipidosis, and generalized hepatocellular necrosis are each identifiable by particular biopsy results and subtle differences in clinical presentation. Risk avoidance strategies in endemic areas include good hand hygiene, avoiding contact with sick people, and avoiding contact with camels and raw or uncooked camel milk or meat. Surveys have demonstrated low disclosure rates of CAM use by patients to their healthcare providers. The ability for providers and organizations to navigate well in a diverse population can help to create a safer and positive healthcare environment for patients to receive care. As antioxidants, they prevent fermentation of wine and discoloration of fruits and vegetables caused by contaminating bacteria. Quality-of-life measures, particularly those related to fatigue or soreness in the hands, feet, mouth, and/or throat, favored pazopanib. The potassium inwardly rectifying channel, subfamily J, member 11 gene (KCNJ11) and the sulfonylurea receptor gene (ABCC8) encode the Kir6.2 and sulfonylurea receptor-1 (SUR1) subunits of pancreatic KATP channels, respectively.