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Patients were required to have an IPSS risk of intermediate-1 or greater; two-thirds of patients had intermediate-2- or high-risk MDS. RV must be measured to determine TLC. MERS cases have also been reported from the United States, Europe, and the Philippines, but all can be linked back to the Arabian Peninsula. The protein glutathione provides a ready source of available sulfhydryl groups within the hepatocyte. The histopathologic findings are nonspecific. The advantages of this model are that the concentration scale is compressed on concentration–effect plots for experiments where wide concentration ranges were used, and the concentration values are transformed so that linear regression can be used to compute model parameters. In addition to the major and minor determinants, unique side-chain determinants may mediate allergy to some penicillins. In general, values obtained with Etest methods are comparable with or even more consistent and accurate than standard methods. The initial increase in growth velocity often is referred to as catch-up growth. When compared to M-mode echocardiography, 2D echocardiography provides increased accuracy in calculating ventricular volumes, wall thickness, and the severity of valvular stenoses. Left atrial enlargement is suspected if the left bronchus is elevated or the atrial appendage is enlarged. Patients who are EMs have a wide range of CYP2D6 activity, with UMs possessing very high enzyme activity on one end of the spectrum and IMs possessing diminished activity on the other end. Four subclasses of type IV reactions (IVa-IVd) have been described based on the responding T cell (eg, T helper type 1 cell, T helper type 2 cell, cytotoxic T cell), effector mechanism (eg, recruitment of macrophages, eosinophils, or neutrophils), and clinical manifestations (eg, contact dermatitis, bullous exanthems, maculopapular eruptions, pustular exanthems) (see Table e88-1). Repolarization of the ventricle leads to the T wave.