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Special attention should be given to adolescents, who may concurrently use alcohol, recreational or illicit drugs, or other prescription or nonprescription medications without the knowledge of the primary healthcare provider, who must attempt to determine their use to avoid drug interactions. In the LEARN model, providers are called to listen to their patients' perceptions of their health with an open mind. Indeed, poor adherence is a major public health challenge, and it makes sense that persons with low health literacy may have even a bigger challenge. Other less commonly recognized sulfonamides include antivirals (amprenavir, fosamprenavir, and darunavir), probenecid, tamsulosin, triptans, and zonisamide. Prolactinomas are classified according to size. Anaphylaxis is an acute, life-threatening reaction, usually mediated by an immune mechanism, that involves multiple organ systems and occurs in 10 to 20 per 100,000 population per year. This nonspecific method also reacts with noncreatinine chromogens in the serum, including bilirubin and proteins such as albumin, and hemoglobin, which may result in a falsely increased Scr. Regardless of the cause, QT prolongation increases susceptibility to a potentially lethal arrhythmia, torsades de pointes (a type of ventricular tachycardia). When using the inhibitory Emax model, a special situation occurs if the baseline effect can be obliterated completely by the drug (eg, decreased premature ventricular contractions during antiarrhythmic therapy). If the bradycardia and hypotension are refractory to the foregoing therapy, a bolus infusion of glucagon (0.05-0.20 mg/kg, initial adult dose is 3-5 mg over 1-2 min) should be considered. The therapy of asthma has been nonspecific; however, in theory, 5-lipoxygenase inhibitors such as zileuton or leukotriene antagonists should provide specific therapy. Because of their pharmacologic action on DNA replication, the antimetabolite class of chemotherapeutic agents is most frequently associated with drug-induced megaloblastic anemia. In the second trial, IFN-О± was compared with medroxyprogesterone acetate 300 mg/day in 350 patients with mRCC. A typical approach involves administering 0.04 to 0.05 mg (0.01 mg/kg in a young child) as the first dose. When the circumstances of a poison exposure indicate that it is minimally toxic, many poisonings can be managed successfully at the scene of the poisoning. Patients with asthma may take nonselective and ОІ1-selective blockers without incident for long periods; however, the occasional report of fatal asthma attacks resistant to therapy with ОІ-agonists should provide ample warning of the dangers inherent in ОІ-blocker therapy.